The announcement comes only a few months after the US President said the US was swamped with immigrants from “s***hole countries” in Africa.
The first lady is planning to make stops in a series of African countries, which will be announced in the next couple of weeks.
She said in a statement: “This will be my first time traveling to Africa and I am excited to educate myself on the issues facing children throughout the continent, while also learning about its rich culture and history.
“We are a global society and I believe it is through open dialogue and the exchanging of ideas that we have a real opportunity to learn from one another.”
Melania’s spokesman, Stephanie Grisham, also said the First Lady looks forward to focussing on humanitarian efforts.
Mrs Trump decided to visit Africa after learning about a series of development programmes which include those focussing on children’s education and wellbeing with investment from the US.
The First Lady has visited many international destinations, but largely while accompanying her husband President Trump.
These destinations have included: Saudi Arabia, Israel, Italy, France, Poland, Turkey, China, South Korea, Japan, England and Belgium.
However, the First Lady’s planned trip to Africa will be her first big solo trip.
The announcement came the same day Mrs Trump was spotted at Rockville in Maryland in support of the Federal Partners in Bullying Prevention (FPBP), part of the Cyberbullying Prevention Summit.
As part of her Be Best campaign, Melania made a speech at the summit, which aims to stop bullying.
She said: “In today’s global society, social media is an inevitable part of our children’s daily lives.
“It can be used in many positive ways, but it can also be destructive and harmful when used incorrectly.
“Let’s face it, most children are more aware of the benefits and pitfalls of social media than some adults.”
It recently emerged that her husband thought the anti-bullying campaign she supported was a bad idea, according to the New York Times.
He reportedly encouraged her to choose a different initiative, as it would leave her open to discussion surrounding her own husband’s reputation on Twitter.